Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder
A study was conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci.
5/13/20251 min read
OCD is a chronic psychiatric disorder that affects 1–3% of the population1 and is characterized by obsessions and compulsions that vary in type and severity and over time. OCD is responsible for profound personal and societal costs2, including increased risk of suicide3 and overall mortality4. OCD is moderately heritable; twin-based heritability estimates range between 27% and 47% in adults and between 45% and 65% in children5,6,7,8, with SNP-based heritability estimates between 28% and 37%9,10,11. Read more here: https://www.nature.com/articles/s41588-025-02189-z